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KMID : 1100620210080020082
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Clinical and Experimental Emergency Medicine
2021 Volume.8 No. 2 p.82 ~ p.88
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Uric acid albumin ratio as a predictive marker of short-term mortality in patients with acute kidney injury
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Ozgur Yasemin
Akın Seydahmet
Yilmaz Nuran Gamze
Gucun Murat
Keskin Ozcan
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Abstract
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Objective: We aimed to investigate uric acid and albumin ratio (UA/A) as a marker of short-term mortality in acute kidney injury (AKI). Both uric acid and albumin are strongly correlated with the development and mortality of AKI.
Methods: The patients hospitalized from May 2019 to September 2019 for AKI were included in this study. The diagnostic odds ratio (DOR), Youden index (J), and the area under a receiver operating characteristic curve (AUROC) determined a cut-off UA/A ratio for mortality. Cox-regression analysis was performed to identify UA/A as a prognostic marker of the 30-day mortality rate.
Results: A total of 171 patients with an average age of 69.20±13.0 (45.6% women) were included in the study. The average UA/A ratio was 3.3±1.5 mg/g and 2.5±1.0 mg/g in the non-survivor and survivor groups, respectively (P=0.001). The best cut-off UA/A ratio associated with mortality was determined as 2.4 mg/g with a specificity of 52% and a sensitivity of 77% (DOR, 3.6; J, 28.8; AUROC, 0.644). Thirty-day cumulative survival rates of the low and high UA/A ratio groups were 85.9±4.0% and 63.7±5.0%, respectively. The estimated survival times of the low and high UA/A ratio groups were 27.7 days (95% confidence interval [CI], 26.2?29.3) and 23.9 days (95% Cl, 22.0?25.9), respectively.
Conclusion: We found a direct correlation between 30-day mortality and UA/A ratio at initial presentation in AKI patients regardless of age, comorbidities, and clinical and laboratory findings, including albuminuria.
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KEYWORD
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Acute kidney injury, Uric acid, Serum albumin, Hypoalbuminemia, Hyperuricemia
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